Stem Cells: From Organic Ideas to Regene...

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Stem cells are the progenitors of specialised cell varieties within the physique and have the power to self-renew. They play vital roles throughout embryonic growth and within the upkeep and restore of grownup tissues. Given their plasticity and regenerative talents, stem cells present alternatives
for treating human ailments akin to diabetes.

Written and edited by specialists within the area, this assortment from Chilly Spring Harbor Views in Biology examines current progress in our understanding of stem cell biology and the way the properties of stem cells could be manipulated for therapeutic functions, emphasizing the roles that cutting-edge
applied sciences and interdisciplinary approaches have performed on this work. The contributors describe how the primary cell lineages come up within the mammalian embryo, stem cell dynamics in the course of the growth and homeostasis of particular tissues (e.g., epithelia and mind), and what occurs when stem cell
integrity is compromised (e.g., by DNA mutations). In addition they discover specialised niches during which stem cells reside (e.g., within the testis and lung) and the way the extracellular cues in these microenvironments regulate stem cell conduct. Many chapters illustrate how single-cell profiling,
stem-cell-derived organoids, intravital microscopy, lineage tracing, quantitative modeling, and different trendy approaches have supplied essential insights.

As well as, the authors contemplate the potential of stem-cell-based therapies within the clinic (e.g., for treating retinal ailments and pores and skin issues) and the improvements which are facilitating the event of these therapies, together with varied lineage reprogramming methods and new biomaterials
that modulate stem cell properties. This quantity is due to this fact an indispensable reference for molecular, cell, and developmental biologists, in addition to anybody wishing to discover the probabilities of stem cells in regenerative drugs and tissue engineering.

Writer‏:‎Chilly Spring Harbor Laboratory Press; 1st version (June 30, 2020)
Language‏:‎English
Hardcover‏:‎324 pages
ISBN-10‏:‎1621823393
ISBN-13‏:‎978-1621823391
Merchandise Weight‏:‎2.05 kilos
Dimensions‏:‎10.2 x 0.6 x 7.3 inches

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